Reg'Activ

Frequently Asked Questions (FAQ)

Probiotics are not just for digestive health. Scientists continue to discover other surprising effects of probiotics. Even mainstream medicine recognizes that, in the future, we may utilize individual probiotic strains to convey specific health benefits.*

With Reg´Activ®, that future is already happening. You may have never heard of these newly discovered probiotic capabilities. Click on a question below to learn more.


Individual Products

Reg´Activ® Product Use and Storage

Glutathione Science


Individual Products


Q. What do Reg´Activ® Products do? Who should take them?
A. All Reg´Activ® Products share one quality in common. They all provide a unique probiotic strain (Lactobacillus fermentum ME-3) that has been found to produce a super antioxidant called glutathione. Every moment of every day, the body uses glutathione to maintain the health of immune system cells, cardiovascular cells, and liver cells. The probiotic component in Reg´Activ® conveys benefits far beyond gut health.*

Right now, there are three Reg´Activ® products that pair the ME-3 probiotic with other benefit-specific ingredients. Choose the product that best resonates with your goals:

Reg´Activ® Cardio Wellness™*
  • Provides antioxidant support for the heart and blood vessels*
  • Promotes healthy processing of LDL*
  • Helps maintain healthy cholesterol levels already in the normal range*
  • Supports healthy energy production in heart muscle tissue*
Reg´Activ® Immune & Vitality™*
  • Supports a healthy immune system*
  • Provides whole body antioxidant support*
  • Supports healthy energy levels and a balanced metabolism*
  • Supports the body’s natural systems for cellular detoxification*
Reg´Activ® Detox & Liver Health™*
  • Helps maintain healthy glutathione levels in the liver*
  • Promotes liver tissue health*
  • Provides both a glutathione-producing probiotic and glutathione precursors*
  • Supports production of super antioxidant enzymes in the liver*
Q. What is in Reg´Activ® CARDIO WELLNESS™? How does it work?
A. Reg´Activ® CARDIO WELLNESS™ provides a unique probiotic strain (Lactobacillus fermentum ME-3) that conveys antioxidant support to heart muscle cells and the cells of the vascular lining (endothelium). The probiotic strain ME-3 has been found to produce the Master Antioxidant molecule called glutathione.*

Every moment of every day, cardiovascular cells utilize glutathione for ongoing maintenance and upkeep. Glutathione is vital for cardio health. Glutathione ultimately helps maintain healthy LDL processing, and it encourages healthy CRP and IL-6 levels and activity. Glutathione is also capable of recycling other heart-health antioxidants such as vitamin C, vitamin E, and coenzyme Q10.*

Reg´Activ® CARDIO WELLNESS™ provides the glutathione-producing probiotic along with:
  • Heart healthy B vitamins (thiamin, B6, B12 methylcobalamin, B5 pantethine) – Help maintain healthy cholesterol levels*
  • Coenzyme Q10 (active form ubiquinol) – Promotes healthy energy production in heart tissue
  • N-Acetyl Cysteine (NAC) – Acts as a glutathione precursor for additional antioxidant support*
Q. What is in Reg´Activ® IMMUNE & VITALITY™? How does it work?
A. Reg´Activ® IMMUNE & VITALITY™ provides a unique probiotic strain (Lactobacillus fermentum ME-3) that conveys antioxidant support to immune system cells. The probiotic strain ME-3 has been found to produce the Master Antioxidant molecule called glutathione. Every day, immune system cells are exposed to common free radicals. These hard-working cells utilize glutathione for their ongoing cellular maintenance and upkeep. Glutathione is imperative for immune health.*

Reg´Activ® IMMUNE & VITALITY™ provides the glutathione-producing probiotic along with:
  • Vitamin C – Trusted antioxidant support for a healthy immune system*
  • Selected B vitamins (thiamin, riboflavin, niacin, B6) – Promote healthy energy levels and balanced metabolic function*
  • L-carnitine tartrate – Helps maintain healthy energy levels
Together, these synergetic ingredients promote a balanced immune response and help maintain energy levels on a cellular level. No other product on the market today approaches immune health in this way.*

Q. What is in Reg´Activ® DETOX & LIVER HEALTH™? How does it work?
A. Reg´Activ® DETOX & LIVER HEALTH™ provides a unique probiotic strain (Lactobacillus fermentum ME-3) that actually produces the Master Antioxidant molecule called glutathione. It is well established that glutathione is required for and regulates virtually all detoxification processes in the body. Every cell in the human body utilizes glutathione for ongoing maintenance and normal detox activities, but the highest concentrations are found in the liver.*

This is because of the liver’s constant handling of day-to-day toxins and associated free radical activity. Of all human body cells, liver cells have the highest demand for glutathione. Healthy glutathione levels are vital for normal liver function.*

Reg´Activ® DETOX & LIVER HEALTH™ provides the glutathione-producing probiotic Lactobacillus fermentum ME-3 along with:
  • L-selenothionine (easy-to-digest selenium) – Promotes healthy levels of the enzyme glutathione peroxidase, which supports liver tissue health*
  • L-methionine & N-acetyl-cysteine (NAC) – Act as glutathione precursors*
  • Milk thistle extract (Silymarin) – Supports production of super antioxidant enzymes in the liver*

Reg´Activ® Product Use and Storage


Q. How should I take Reg´Activ®?
A. For all products in the Reg´Activ® line, take 2 capsules daily, 30 minutes before a meal or as directed by a health care professional. For optimal effects, maintain a balanced diet and healthy lifestyle.

Q. How should I store Reg´Activ®?
A. The robust probiotic used in Reg´Activ® does not need to be refrigerated. Simply keep your Reg´Activ® products in a cool dry place.

Q. Should I take both Reg´Activ® and Dr. Ohhira’s Probiotics®?
A. Both Reg´Activ® and Dr. Ohhira’s Probiotics® contain a probiotic component. However, the strains utilized by these two product lines are radically different and work on separate body systems.

Dr. Ohhira’s Probiotics® Original and Pro Formulas are still the best approach to addressing complex digestive wellness goals and immune health goals connected to gut health. Meanwhile, Reg´Activ® products provide a probiotic strain that produces glutathione—which affects immune health, but also has implications for cardio health and liver function.*

Taking both products can be highly synergetic for some individuals. But all people should talk to a health care provider before making additions or changes to their supplement protocol. Some mild digestive discomfort can occur when taking multiple probiotic products. Your health care provider can advise you on dosages and timing when you take each product.*

Q. Is Reg´Activ® safe to take if I’m allergic/sensitive to one of the ingredients?
A. Allergies to Reg´Activ®’s ingredients are incredibly rare, but if you have been diagnosed with an allergy or sensitivity to one of the ingredients, do not take the product. Speak with your primary health care provider if you have any questions about ingredient allergy or sensitivity.

Q. Will any ingredient in Reg´Activ® interact with my prescription medication?
A. No, Reg´Activ® products are not known to interact with any medications. However, all patients should speak with their primary health care providers before adding supplements to an existing prescription medication protocol.

Q. Are Reg´Activ® products safe for children?
A. Glutathione is especially valuable for children with specific detox and immune health goals. However, the current product line provides dosage recommendations that are designed for adults, ages 18 and older. Please speak with your primary health care provider about appropriate dosage and administration for children.

Glutathione Science


Q. What is glutathione? What’s so important about another antioxidant?
A. We hear about antioxidants all the time. But you might not be familiar with glutathione. In the research community, glutathione is actually referred to as the Master Antioxidant. Consisting of three amino acids (glutamate, cysteine, and glycine), it is produced and used by EVERY cell in the human body. Glutathione is that important.

Glutathione’s primary function is to address the day-to-day effects of free radicals in every human cell. Glutathione is also called the Master Detoxifier because it plays a vital role in regulating detoxification reactions throughout the body. Glutathione is clearly more than “just another antioxidant.” It is the body’s main antioxidant tool for maintaining the wellness of every cell.*

Reg´Activ® products are revolutionary in that they provide a probiotic strain that actually produces and recycles spent glutathione from within the body. No other supplement product provides glutathione in this highly effective fashion.*

Q. Why can’t I just take a glutathione supplement? What makes Reg´Activ® different?
A. Glutathione is not effective when taken orally. Even the newer liposomal delivery forms of glutathione get oxidized fairly quickly after absorption. This is a well-known challenge in the medical research community. Only Reg´Activ® effectively addresses this supplementation challenge.

All Reg´Activ® products provide a unique probiotic strain, Lactobacillus fermentum ME-3, which produces glutathione from within the body. There’s no concern about the glutathione breaking down before it can get to the cells that need it. ME-3 produces glutathione live, inside the person. In a human clinical trial, volunteers taking ME-3 saw an impressive 49% promotion of their ratios of active (reduced) to spent (oxidized) glutathione.*

It’s clear that this innovative, probiotic-produced glutathione is the most efficient and effective approach to supporting healthy glutathione levels.*

Q. How does the Reg´Activ® probiotic strain (Lactobacillus fermentum ME-3) support glutathione levels?
A. ME-3 is capable of maintaining healthy glutathione levels by three different mechanisms. Each daily dose of Reg´Activ® contains 4 to 6 billion ME-3 bacteria, which are capable of:*
  • Actually producing glutathione from within the human body*
  • Extracting glutathione from the surrounding environment*
  • Recycling spent (oxidized) glutathione back to its active (reduced) state*
Because Lactobacillus fermentum ME-3 can promote glutathione levels via 3 different mechanisms, scientists are calling this strain a “Complete Glutathione System”. It is worth emphasizing that nothing before has ever been discovered that can maintain glutathione levels through three different mechanisms.*

Q. How does glutathione support antioxidant activity in the body?*
A. The unique probiotic strain in Reg´Activ® products (Lactobacillus fermentum ME-3) is capable of producing antioxidant glutathione from within the human body. ME-3 is also able to recycle or regenerate spent (oxidized) glutathione back to its active (reduced) antioxidant state. ME-3’s natural activities help to recycle or reactivate other spent antioxidants such as: vitamin C, vitamin E, coenzyme Q10, and lipoic acid.*

As another side benefit, ME-3 synthesizes a very important intracellular antioxidant called manganese superoxide dismutase (Mn-SOD). This ability to produce both glutathione and Mn-SOD, makes ME-3 an antioxidant superstar. In human trials, people taking ME-3 exhibited an impressive 49% promotion of their ratios of active (reduced) to spent (oxidized) glutathione and 26% promotion in Total Antioxidant Activity (TAA) throughout the body.*

Q. How does taking Reg´Activ® promote healthy detoxification?*
A. There are numerous detox programs on the market today, and they address detoxification from a variety of perspectives, ranging from liver health to colon cleansing.

All Reg´Activ® products support detoxification to some degree because they help maintain healthy glutathione levels. Though the liver is certainly the biggest consumer of glutathione, the effects are not limited solely to the liver. Glutathione actually promotes healthy detoxification activities in every cell in the body. So its effects are more far-reaching than many other supplements with limited organ-specific benefits.*

Glutathione is known for its ability to assist with day-to-day detoxification of chemicals in our modern environment. This includes common agricultural and residential lawn and garden chemicals (such as glyphosate and organophosphates). Glutathione is also vital for the healthy processing and elimination of alcohol, prescription and over-the-counter medications, and certain metals often present in our foods and the environment.*

As exposures to all of these chemicals increase, the body’s demand for glutathione increases. In our modern world, the body needs more glutathione. Supplementing with a Reg´Activ® product can successfully address this increased glutathione-demand.*

Q. How was the Reg´Activ® probiotic strain (Lactobacillus fermentum ME-3) discovered?
A. Lactobacillus fermentum ME-3 was isolated from the intestinal tract of a healthy one-year old child in 1995. It was the discovery of award-winning microbiologist Marika Mikelsaar, MD, PhD and her team of research scientists at the University of Tartu, Estonia.

Ongoing research revealed that ME-3 could support healthy glutathione levels via three different mechanisms. In addition to synthesizing glutathione, the bacteria can also extract it from the surrounding environment and recycle spent (oxidized) glutathione back to its active (reduced) form. Consequently, ME-3 is being called a “Complete Glutathione System”. There is no other known probiotic strain or supplement that provides this 3-prong glutathione effect.*

Q. What is Lactobacillus brevis KP08 and why is it added to the Reg´Activ® Immune & Vitality formula?
A. Lactobacillus brevis KP08 is a strain of probiotic bacteria that provides unique immune system-supporting properties. Studies report that KP08 promotes the production of interferon-alpha and the activity of 2-5 synthetase. Both of these functions are powerful activities in the immune system’s handling of common day-to-day challenges.

KP08 also supports normal activity of natural killer cells (NK activity). Natural killer (NK) cells are an important part of the body’s frontline immune response—addressing common challenges that come from outside the body and maintaining healthy cellular apoptosis within the body.*

As of this date (March 2016), there are 15 publications on the various functions and benefits of KP08 (KB290) that appear in the PubMed database. When searching for information about this species on your own, it is helpful to know that the official name of Lactobacillus brevis KP08 is “Lactobacillus brevis subspecies coagulans”. It is also sometimes referred to as KB290. Sometimes a bacterial strain will have more than one commercial name. Both KP08 and KB290 refer to Lactobacillus brevis subspecies coagulans.

KP08 was discovered in Japan where it is actually quite popular due to its proven immune system-supporting properties. As far as we know, our Reg´Activ® Immune & Vitality formula is the first probiotic product outside of Japan to utilize KP08.*

Q. Why does Reg´Activ® Immune & Vitality contain only 4 billion ME-3 bacteria per daily dose (2 capsules), whereas Cardio Wellness and Detox & Liver Health provide 6 billion ME-3 bacteria per dose?
A. The lower ME-3 dosage in the Immune & Vitality formula simply “makes room” for the added KP08 strain. We felt this was appropriate for the Immune & Vitality formula since KP08 adds powerful synergistic support for immune system activity.*





Copyright © 2016 by Essential Formulas Incorporated

Essential Formulas Incorporated · P.O.Box 166139 · Irving, TX 75016-6139

972.255.3918 (phone) · 972.255.6648 (fax)

 * These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.